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Genomics & Proteomics Past Projects

Designed and Fabricated an Optical Flow Cell for Novel DNA Sequencing by Synthesis Instrumentation. 

Redesigned and Fabricated the optomechanics and optical system of a commercially available fluorescence-based DNA sequencer to provide for ease of manufacturability, maximum resolution and light collection efficiency.

Designed and Fabricated a Commercially Available CCD-based Microarray Imaging System with Novel Illumination.

Designed and Fabricated a Microarray Reader utilizing Evanescent-Wave Excitation to Reduce Background.

Designed the Optomechanical and Optical systems of an Ultra-High-Throughput Single Nucleotide Polymorphism (SNP) detection instrument.  This instrument is in regular use in a commercial setting.

Co-invented, designed and built the core technology for Illumina's array-of-arrays platform.

Designed and implemented automated sample handling for microarray imaging systems.  Ninety-six individual microarrays are automatically imaged without operator intervention.

Designed and constructed prototypes of multi-color fluorescence imaging systems for ultra-high density DNA microarrays (3 micron samples).

Conceived of and developed novel microfluidic technologies for use in Genomics applications.

Working closely with molecular biologists, designed and built the world's fastest automated DNA sequencing instrument based on the Multiplex Sequencing methodology developed by Dr. George Church at the Harvard University Medical School.

Developed methodology and instrumentation to create ultra-high-density micro-arrays of cDNAs and oligonucleotides for differential gene expression and genetic mutation analysis.  Also designed a CCD-based two-color fluorescence imaging system for such arrays.

Developed a membrane-based high-resolution DNA grid hybridization and imaging instrument for positional cloning of disease genes.

Designed system integration and automation of high-throughput DNA sequencing chemistries with large scale 96 and 384-well sample plate handling and storage for automated sequence finishing.

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